Season 2004/2005
Key: F - Friendlies; T - Tournament; L - League; C - Champions League; CC - Carling Cup; FA - FA Cup
| Date | Opponents | Compn | Score | Posn | Scorers |
| 25/7 | Bayern Munich | Tour | 0-0 | - | - |
| 28/7 | Celtic | Tour | 1-2 | - | Smith |
| 31/7 | AC Milan | Tour | 1-1 | - | Scholes |
| 3/8 | PSV Eindhoven | Fr | 1-0 | - | Silvestre |
| 8/8 | Arsenal | C Shield | 1-3 | - | Smith |
| 11/8 | Dynamo Bucharest | CLQ | 2-1 | - | Giggs, 1 og |
| 15/8 | Chelsea | L | 0-1 | - | - |
| 21/8 | Norwich | L | 2-1 | - | Bellion, Smith |
| 25/8 | Dynamo Bucharest | CLQ | 3-0 | - | Smith 2, Bellion |
| 28/8 | Blackburn | L | 1-1 | - | Smith |
| 30/8 | Everton | L | 0-0 | - | - |
| 11/9 | Bolton | L | 2-2 | - | Heinze, Bellion |
| 15/9 | Lyon | CL | 2-2 | - | van Nistelrooy (2) |
| 20/9 | Liverpool | L | 2-1 | 8 | Silvestre (2) |
| 25/9 | Tottenham | L | 1-0 | 4 | van Nistelrooy |
| 28/9 | Fenerbahce | CL | 6-2 | - | Rooney (3); Giggs; Bellion; van Nistelrooy |
| 3/10 | Middlesboro | L | 1-1 | 4 | Alan Smith |
| 16/10 | Birmingham | L | 0-0 | 5 | - |
| 19/10 | Sparta Prague | CL | 0-0 | - | - |
| 24/10 | Arsenal | L | 2-0 | 5 | van Nistelrooy; Rooney |
| 26/10 | Crewe | CC | 3-0 | - | Smith, Miller, Foster (og) |
| 30/10 | Portsmouth | L | 0-2 | 7 | - |
| 3/11 | Sparta Prague | CL | 4-1 | - | van Nistelrooy (4) |
| 7/11 | Man City | L | 0-0 | 7 | - |
| 10/11 | Crystal Palace | CC | 2-0 | - | Saha, Richardson |
| 14/11 | Newcastle | L | 3-1 | 5 | Rooney (2), van Nistelrooy |
| 20/11 | Charlton | L | 2-0 | 5 | Giggs, Scholes |
| 23/11 | Lyon | CL | 2-1 | - | G Neville, van Nistelrooy (Qualified for Knockout) |
| 27/11 | West Brom | L | 3-0 | 4 | Scholes 2, van Nistelrooy |
| 1/12 | Arsenal | CC | 1-0 | - | Bellion |
| 4/12 | Southampton | L | 3-0 | 4 | Scholes, Rooney, Ronaldo |
| 8/12 | Fenerbahce | CL | 0-3 | - | Already Qualified |
| 13/12 | Fulham | L | 1-1 | 4 | Smith |
| 18/12 | Crystal Palace | L | 5-2 | 4 | Scholes 2; Smith, Boyce (og), O'Shea |
| 26/12 | Bolton | L | 2-0 | 3 | Giggs, Scholes |
| 28/12 | Aston Villa | L | 1-0 | 3 | Giggs |
| 1/1 | Middlesbrough | L | 2-0 | 3 | Fletcher, Giggs |
| 4/1 | Tottenham | L | 0-0 | 3 | - |
| 8/1 | Exeter | FA3 | 0-0 | - | - |
| 12/1 | Chelsea | CCQF1 | 0-0 | - | - |
| 15/1 | Liverpool | L | 1-0 | 3 | Rooney |
| 19/1 | Exeter | FA3 | 2-0 | - | Ronaldo, Rooney |
| 22/1 | Aston Villa | L | 3-1 | 3 | Ronaldo, Saha, Scholes |
| 26/1 | Chelsea | CCQF2 | 1-2 | - | Giggs |
| 29/1 | Middlesbrough | FA4 | 3-0 | - | O'Shea, Rooney 2 |
| 1/2 | Arsenal | L | 4-2 | 2 | Ronaldo 2, Giggs, O'Shea |
| 5/2 | Birmingham | L | 2-0 | 2 | Keane, Rooney |
| 13/2 | Man City | L | 2-0 | 2 | Rooney, Dunne (og) |
| 19/2 | Everton | FA5 | 2-0 | - | Fortune, Ronaldo |
| 23/2 | AC Milan | CLQF | 0-1 | - | - |
| 26/2 | Portsmouth | L | 2-0 | 2 | Rooney (2) |
| 5/3 | Crystal Palace | L | 0-0 | 2 | - |
| 8/3 | AC Milan | CLQF | 0-1 | - | - |
| 12/3 | Southampton | FAQF | 4-0 | - | Scholes 2, Ronaldo, Keane |
| 19/3 | Fulham | L | 1-0 | 2 | Ronaldo |
| 2/4 | Blackburn | L | 0-0 | 2 | - |
| 9/4 | Norwich | L | 0-2 | 3 | - |
| 17/4 | Newcastle | FASF | 4-1 | - | van Nistelrooy 2, Scholes, Ronaldo |
| 20/4 | Everton | L | 0-1 | 3 | - |
| 24/4 | Newcastle | L | 2-1 | 3 | Rooney, Brown |
| 1/5 | Charlton | L | 4-0 | 3 | Scholes, Fletcher, Rooney, Smith |
| 7/5 | West Brom | L | 1-1 | 3 | Giggs |