Key: F - Friendlies; T - Tournament; L - League; CL - Champions League; CC - Carling Cup; FA - FA Cup
| Date | Opponents | Home/Away | Competition | Score | Position | Scorers |
| 12/07 | Aberdeen | A | F | 2-0 | - | Carrick, Rooney |
| 19/07 | Kaizer Chiefs | A | F | 1-1 | - | Eagles |
| 22/07 | Orlando Pirates | A | F | 1-0 | - | Martin |
| 26/07 | Final v Kaizer Chiefs | A | F | 4-0 | - | Giggs, Rooney, Cleverley, Campbell |
| 27/07 | Portsmouth | Nigeria | F | 2-1 | - | Eagles, Tevez |
| 02/08 | Espanyol | H | Ole Test'l | 1-0 | - | Campbell |
| 04/08 | Peterborough | A | F | |||
| 06/08 | Juventus | H | F | 0-0 | ||
| 10/08 | Portsmouth | Wembley | C Shield | 0-0 | Won 3-1 on penalties | |
| 16/08 | Newcastle | H | L | 1-1 | - | Fletcher |
| 23/08 | Portsmouth | A | L | 1-0 | 5 | Fletcher |
| 29/08 | Zenit St Petersburg | Monaco | Euro S Cup | 1-2 | - | Vidic |
| 13/09 | Liverpool | A | L | 1-2 | 13 | Tevez |
| 17/09 | Villarreal | H | CL | 0-0 | - | - |
| 20/09 | Chelsea | A | L | 1-1 | 15 | Park |
| 24/09 | Middlesbrough | H | CC3 | 3-1 | - | Ronaldo, Giggs, Nani |
| 27/09 | Bolton | H | L | 2-0 | 11 | Ronaldo (pen) Rooney |
| 30/09 | Aarlborg | A | CL | 3-0 | - | Rooney, Berbatov 2 |
| 04/10 | Blackburn | A | L | 2-0 | 6 | Brown, Rooney |
| 18/10 | West Brom | H | L | |||
| 21/10 | Celtic | H | CL | |||
| 25/10 | Everton | A | L | |||
| 29/10 | West Ham | H | L | |||
| 10/11 | QPR | H | CC4 | |||